HOMA-IR — the Homeostatic Model Assessment of Insulin Resistance — is a calculated measure derived from two simple blood values: fasting glucose and fasting insulin. It is the most clinically accessible method for detecting insulin resistance before type 2 diabetes develops.
Why standard diabetes screening misses early insulin resistance
The Swiss standard diabetes screening protocol measures fasting glucose and HbA1c. Both can remain normal for a decade or more while insulin resistance silently worsens. The reason: your pancreas compensates by producing increasing amounts of insulin to maintain normal glucose. HOMA-IR catches this compensation. A normal glucose with an elevated fasting insulin is exactly the pattern HOMA-IR is designed to detect.
How HOMA-IR is calculated
HOMA-IR = (Fasting insulin in mU/L × Fasting glucose in mmol/L) ÷ 22.5
Interpretation: below 1.0 is optimal, 1.0–1.9 is normal range, above 1.9 suggests early insulin resistance, above 2.9 indicates significant insulin resistance. This formula was developed at Oxford University and has been validated in dozens of population studies.
Who should get a HOMA-IR test?
HOMA-IR is particularly valuable if you have: abdominal weight gain despite controlled diet, fatigue after meals, family history of type 2 diabetes, PCOS, elevated triglycerides with low HDL, or non-alcoholic fatty liver disease. All of these conditions are associated with the insulin-resistant phenotype that HOMA-IR detects.
Getting a HOMA-IR test in Switzerland
Fasting insulin is rarely included in standard Swiss GP blood panels — it requires a specific order. Aeonix includes both fasting insulin and HOMA-IR calculation in every screening plan, alongside glucose and HbA1c, giving you the full metabolic picture rather than just a single data point.